Collagen alpha-1(IX) chain/COL9A1 Protein, Human (HEK293, His)

Collagen alpha-1(IX) chain (COL9A1) is one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage and a structural component of vitreous in the eye. Synthesis of COL9A1 chain is essential for assembly of type IX collagen molecules, and mutations of COL9A1 are associated with osteoarthritis in humans, multiple epiphyseal dysplasia, and Stickler syndrome. Collagen alpha-1 (IX) chain/COL9A1 Protein, Human (HEK293, His) is the recombinant human-derived Collagen alpha-1(IX) chain/COL9A1 protein, expressed by HEK293 , with C-6*His labeled tag.

Collagen alpha-1(IX) chain (COL9A1) is one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage and a structural component of vitreous in the eye. COL9A1 has two isoforms through alternative slice. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Synthesis of COL9A1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in COL9A1 are associated with osteoarthritis in humans, multiple epiphyseal dysplasia, and Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects^[1][2][3][4].

Human

HEK293

C-6*His

P20849-3 (A24-P328)

1297  [NCBI]

Partial

AVKRRPRFPVNSNSNGGNELCPKIRIGQDDLPGFDLISQFQVDKAASRRAIQRVVGSATLQVAYKLGNNVDFRIPTRNLYPSGLPEEYSFLTTFRMTGSTLKKNWNIWQIQDSSGKEQVGIKINGQTQSVVFSYKGLDGSLQTAAFSNLSSLFDSQWHKIMIGVERSSATLFVDCNRIESLPIKPRGPIDIDGFAVLGKLADNPQVSVPFELQWMLIHCDPLRPRRETCHELPARITPSQTTDERGPPGEQGPPGPPGPPGVPGIDGIDGDRGPKGPPGPPGPAGEPGKPGAPGKPGTPGADTSP

Approximately 38-50 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.