Cyclin A1 Protein, Human (sf9, His)

Cyclin A1 Protein emerges as a pivotal regulator in the intricate control of the cell cycle, exerting influence at the G1/S (start) and G2/M (mitosis) transitions. Its role extends beyond somatic cells, as it appears to be primarily involved in governing the germline meiotic cell cycle, with additional functions in the mitotic cell cycle of certain somatic cells. Through interactions with CDK2 and CDC2 protein kinases, Cyclin A1 forms a serine/threonine kinase holoenzyme complex, where the cyclin subunit confers substrate specificity. Notably, it does not bind CDK4 and CDK5 in vitro. The Cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins, underscoring its involvement in crucial regulatory pathways. Furthermore, it participates in complexes with CDK2, CABLES1, and CCNE1, indicating its multifaceted interactions within the cell cycle regulatory network. Interactions with INCA1 and KLHDC9 further highlight the intricate molecular associations that contribute to Cyclin A1's role in cell cycle regulation. Unraveling the specific mechanisms governing Cyclin A1's interactions and functions could provide valuable insights into its regulatory impact on both meiotic and mitotic cell cycles.