CCNA1 - cyclin A1 Gene
Also Known as CT146
Species: Homo sapiens
About CCNA1
This gene has 4 transcripts (splice variants), 213 orthologues and 18 paralogues. Restricted expression toward testis (RPKM 24.4).
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the Other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
CCNA1 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001111045.4 | NP_001104515.2 | cyclin-A1 |
| NM_001111046.2 | NP_001104516.1 | cyclin-A1 |
| NM_001111047.2 | NP_001104517.1 | cyclin-A1 |
| NM_001413923.1 | NP_001400852.1 | cyclin-A1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
8756624 | GOA |
CCNA1 Protein Structure
Cyclin_N: Cyclin, N-terminal domain (214 - 340)
Cyclin_C: Cyclin, C-terminal domain (342 - 459)
- 0
- 100
- 200
- 300
- 400
- 465 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cyclin-A1 |
|
CCNA1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CCNA1 | P78396 | CDKN1A | Homo sapiens | P38936 | 25241761 |
Recombinant CCNA1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72962 | Cyclin A1 Protein, Human (sf9, His) | P78396 (M1-Q465) | ≥ 95%, as determined by reducing SDS-PAGE. |
CCNA1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80631 | Cyclin A1 Antibody | WB, IHC-F, IHC-P, ICC/IF, ELISA | Human, Mouse, Rat, Monkey |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Myeloid Leukemia |
|
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| Testicular Cancer |
|
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| Male Infertility |
|
|
| Infertility |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Lung Cancer |
|
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| Gastric Cancer |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-180196 | EGFR-IN-187 | / | Unkown | |
| HY-RS02116 | CCNA1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS19991 | Ccna1 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS26495 | Ccna1 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | CCNA1 | VGNC | VGNC:26956 |
| Rattus norvegicus | CCNA1 | RGD | RGD:1310639 |
| Canis familiaris | CCNA1 | VGNC | VGNC:38892 |
| Macaca mulatta | CCNA1 | VGNC | VGNC:70718 |
| Felis catus | CCNA1 | VGNC | VGNC:60550 |
| Mus musculus | CCNA1 | MGD | MGI:108042 |
| Others | CCNA1 | NCBI |
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