EGFR-IN-187
EGFR-IN-187 (Compound 4d) is a selective EGFR inhibitor with an IC50 of 25.41 μM. EGFR-IN-187 can cause cancer cells S amd G2/M phase arrest and induce apoptosis and autophagy. EGFR-IN-187 upregulates CCNE1, Bax, LC3B-II and P27 expression and downregulates CCNA1 and Bcl-2 levels. EGFR-IN-187 can be used for the research of cancer, such as lung cancer.
For research use only. We do not sell to patients.
- Formula: C21H23N3O3S
- Molecular Weight:397.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
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Bcl-2 |
Bax |
LC3B-II |
CCNE1 |
CCNA1 |
P27 |
EGFR-IN-187 shows inhibitory activity against PANC-1 and A549 cells with IC50 values of 0.067 and 2.29 μM and SI of 1521 and 21 fold[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 397.49
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Formula C21H23N3O3S
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SMILES
CC1=NC2=C(N1CC(NC3=C(C4=C(S3)CCC4)C(OC(C)C)=O)=O)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-187 Related Classifications
HY-180196 Related Classifications
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