2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Receptor Superfamily
  6. EDA2R
  7. EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc)

EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc)

Cat. No.: HY-P77354
Handling Instructions

EDA2R Protein, also known as EDA-2R and TNFRSF27, is a transmembrane protein in the TNF receptor superfamily. EDA2R Protein is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles, and it does not contain a cytoplasmic death domain. EDA2R Protein can associate with Fas and induce EDA-A2 dependent apoptosis. EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc) is 136 a.a., with molecular weight of ~116 & 58 & 53 kDa, respectively.

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Description

EDA2R Protein, also known as EDA-2R and TNFRSF27, is a transmembrane protein in the TNF receptor superfamily. EDA2R Protein is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles, and it does not contain a cytoplasmic death domain. EDA2R Protein can associate with Fas and induce EDA-A2 dependent apoptosis. EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc) is 136 a.a., with molecular weight of ~116 & 58 & 53 kDa, respectively.
Background

EDA2R Protein plays a role in EDA‑A2 induced skeletal muscle degeneration and osteoblast differentiation. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent[1][2][3].
Species

Cynomolgus
Source

HEK293
Tag

C-hFc
Accession

NP_001180396 (M1-E136)
Gene ID

102116506  [NCBI]
Molecular Construction
N-term
EDA2R (M1-E136)
Accession # NP_001180396
hFc
C-term
Synonyms
Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR
Molecular Weight

Approximately 116&58&53 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc)
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