Epstein-Barr virus Glycoprotein gp350/GP350 Protein (sf9, His)

The Epstein-Barr viral glycoprotein gp350 (GP350) is critical for initiating attachment of viral particles to host B lymphocytes, a critical step in viral entry. By binding to host CR2 on B lymphocytes, GP350 promotes the subsequent binding of the viral glycoprotein gp42 to HLA class II molecules. Epstein-Barr virus Glycoprotein gp350/GP350 Protein (sf9, His) is the recombinant Virus-derived Epstein-Barr virus Glycoprotein gp350/GP350 protein, expressed by Sf9 insect cells , with C-His labeled tag.

Epstein-Barr virus Glycoprotein gp350 (GP350) plays a pivotal role in initiating virion attachment to host B-lymphocyte cells, a crucial step in the virus entry process. GP350 achieves this by binding to host CR2 at the surface of B-lymphocytes, thereby facilitating the subsequent binding of viral glycoprotein gp42 to HLA class II molecules. This attachment event triggers the fusion of the virion with the host cell membrane, leading to the invasion of the host cell by the virus. The interaction between GP350 and host CR2 is a key molecular interaction central to the initial stages of Epstein-Barr virus infection.

Virus

Sf9 insect cells

C-His

P03200 (M1-P490)

3783713  [NCBI]

Partial

MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTP

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.