FAM171B Protein, Human (HEK293, His)

FAM171B may play a role in the progression of pulmonary hypertension by stimulating immune infiltration and immune response. FAM171B promotes tumor progression by stabilizing vimentin in the cytoplasm. FAM171B is a candidate gene for a neurodegenerative disease whose molecules have not yet been characterized. FAM171B Protein, Human (HEK293, His) is the recombinant human-derived FAM171B protein, expressed by HEK293 , with C-His labeled tag.

FAM171B is a widely expressed evolutionarily conserved protein. FAM171B may play a role in the progression of pulmonary hypertension by stimulating immune infiltration and immune response. FAM171B promotes tumor progression by stabilizing vimentin in the cytoplasm. FAM171B is a candidate gene for a neurodegenerative disease whose molecules have not yet been characterized^[1][2][3].

Human

HEK293

C-6*His

AAH60872 (R31-T355)

165215  [NCBI]

Partial

RAELSRSDLSLIQQQQQQQQQQQQQQQQKQLEEAEEERTEVPGATSTLTVPVSVFMLKVQVNDIISRQYLSQAVVEVFVNYTKTNSTVTKSNGAVLIKVPYKLGLSLTIIAYKDGYVLTPLPWKTRRMPIYSSVTLSLFPQSQANIWLFEDTVLITGKLADAKSQPSVQFSKALIKLPDNHHISNVTGYLTVLQQFLKVDNFLHTTGITLNKPGFENIELTPLAAICVKIYSGGKELKVNGSIQVSLPLLRLNDISAGDRIPAWTFDMNTGAWINHGRGMVKEHNNHLIWTYDAPHLGYWIAAPLPGTRGSGINEDSKDITAYHT

Approximately 43-57 kDa due to the glycosylation.

• 
  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Hu WM, et al. FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression. J Exp Clin Cancer Res. 2023 Nov 2;42(1):290.  [Content Brief]

  [2]. Tran Q, et al. FAM171B is a novel polyglutamine protein widely expressed in the mammalian brain. Brain Res. 2021 Sep 1;1766:147540.  [Content Brief]

  [3]. Qu LH, et al. FAM171B as a Novel Biomarker Mediates Tissue Immune Microenvironment in Pulmonary Arterial Hypertension. Mediators Inflamm. 2022 Sep 22;2022:1878766.  [Content Brief]