Ferritin heavy chain/FTH1 Protein, Human

The ferritin heavy chain/FTH1 protein is critical for maintaining iron homeostasis, storing iron in soluble form through ferroxidase activity. It promotes the oxidation of ferrous iron so that it can be deposited in the form of iron hydroxide. Ferritin heavy chain/FTH1 Protein, Human is the recombinant human-derived Ferritin heavy chain/FTH1 protein, expressed by E. coli , with tag free.

Ferritin heavy chain/FTH1 protein serves a crucial role in iron homeostasis by storing iron in a soluble and non-toxic form. With ferroxidase activity, it facilitates the oxidation of ferrous iron, allowing its deposition as ferric hydroxides. Beyond iron storage, this protein also contributes to the delivery of iron to cells, emphasizing its multifaceted function. Moreover, FTH1 is implicated in mediating iron uptake in capsule cells during kidney development, further highlighting its significance in various physiological processes.

Immobilized Human FTH1 at 2 μg/mL (100 μL/well) can bind FTH1 antibody .The ED₅₀ for this effect is 1-5 ng/mL.

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  Immobilized Human FTH1 at 2 μg/mL (100 μL/well) can bind FTH1 antibody .The ED₅₀ for this effect is 2.771 ng/mL.

Human

E. coli

Tag Free

P02794 (M1-S183)

2495  [NCBI]

Full Length

MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES

Approximately 22 kDa

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  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder

1.Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
2.Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
3.Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
Please refer to the lot-specific COA for specific buffer information.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.