Glycoprotein B/gB Protein, CyCMV (HEK293, Fc)

Glycoprotein B (gB) is a key envelope glycoprotein. gB plays a key role in the fusion of viruses and cell membranes, facilitating the entry of viruses into host cells. gB interacts with heparin sulfate proteoglycans and is associated with gH/gL heterodimers. gB is activated by TLR2 and MyD88/ TRAF6-dependent signaling pathways NF-κB. Glycoprotein B/gB Protein, CyCMV (HEK293, Fc) is the recombinant Virus-derived Glycoprotein B/gB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Glycoprotein B/gB Protein, CyCMV (HEK293, Fc) is 453 a.a., with molecular weight of ~102.5 KDa.

Glycoprotein B (gB) is a key envelope glycoprotein that forms unique spikes on the surface of virions and plays a crucial role in the initial attachment of the heparin sulfate portion of proteoglycans on the surface of host cells. This interaction is a fundamental step in the virus entry process. In addition, gB plays a key role in the fusion of viruses and cell membranes, facilitating the entry of viruses into host cells. The complex fusion mechanisms required for this process include at least gB and gH/gL heterodimers. In addition to adhesion and membrane fusion upon entry into the host cell, gB may also be involved in the fusion of the virion envelope with the outer nuclear membrane upon the departure of the virion. As a trimer linked by disulfide bonds, gB interacts with heparin sulfate proteoglycans and forms associations with gH/gL heterodimers, further emphasizing its multifaceted function in the viral life cycle. gB is activated by TLR2 and MyD88/ TRAF6-dependent signaling pathways NF-κB^[1][2][3].

Virus

HEK293

C-hFc

ADV35145 (A228-D680, with cleavage site mutated RHKR to TTQT)

/

Approximately 102.5 kDa.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.