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  5. GUCY2C/Guanylyl cyclase C Protein, Canine (HEK293, His)

GUCY2C/Guanylyl cyclase C Protein, Canine (HEK293, His)

Cat. No.: HY-P77680
Handling Instructions

GUCY2C, a guanylyl cyclase, crucially catalyzes cGMP synthesis from GTP. As a receptor for E. coli heat-stable enterotoxin, GUCY2C significantly stimulates cGMP accumulation in mammalian cells, emphasizing its role in mediating responses to specific external stimuli and showcasing intricate regulatory mechanisms in cellular signaling. GUCY2C/Guanylyl cyclase C Protein, Canine (HEK293, His) is the recombinant canine-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Canine (HEK293, His) is 410 a.a., with molecular weight of 75-80 kDa.

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Description

GUCY2C, a guanylyl cyclase, crucially catalyzes cGMP synthesis from GTP. As a receptor for E. coli heat-stable enterotoxin, GUCY2C significantly stimulates cGMP accumulation in mammalian cells, emphasizing its role in mediating responses to specific external stimuli and showcasing intricate regulatory mechanisms in cellular signaling. GUCY2C/Guanylyl cyclase C Protein, Canine (HEK293, His) is the recombinant canine-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Canine (HEK293, His) is 410 a.a., with molecular weight of 75-80 kDa.
Background

GUCY2C, a guanylyl cyclase, plays a pivotal role in catalyzing the synthesis of cyclic (cGMP) from GTP. Acting as a receptor for the E. coli heat-stable enterotoxin, GUCY2C responds to the toxin by significantly stimulating the accumulation of cin mammalian cells expressing this protein. This interaction highlights the intricate regulatory mechanisms involved in cellular signaling and emphasizes the role of GUCY2C in mediating responses to specific external stimuli.
Species

Canine
Source

HEK293
Tag

C-His
Accession

F1PAG3 (Y21-Q430)
Gene ID

/
Molecular Construction
N-term
GUCY2C (Y21-Q430)
Accession # F1PAG3
His
C-term
Synonyms
Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; MUCIL
Molecular Weight

75-80 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

GUCY2C/Guanylyl cyclase C Protein, Canine (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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