GUCY2C/Guanylyl cyclase C Protein, Cynomolgus (HEK293, His)

GUCY2C, a guanylyl cyclase, crucially catalyzes cGMP synthesis from GTP. As a receptor for E. coli heat-stable enterotoxin, GUCY2C significantly stimulates cGMP accumulation in mammalian cells, emphasizing its role in mediating responses to specific external stimuli and showcasing intricate regulatory mechanisms in cellular signaling. GUCY2C/Guanylyl cyclase C Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-His labeled tag.

GUCY2C, a guanylyl cyclase, plays a pivotal role in catalyzing the synthesis of cyclic (cGMP) from GTP. Acting as a receptor for the E. coli heat-stable enterotoxin, GUCY2C responds to the toxin by significantly stimulating the accumulation of cin mammalian cells expressing this protein. This interaction highlights the intricate regulatory mechanisms involved in cellular signaling and emphasizes the role of GUCY2C in mediating responses to specific external stimuli.

Cynomolgus

HEK293

C-8*His

XP_005570270 (S24-Q430)

102130850  [NCBI]

Partial

SQVSQNCHNGSYEISVLMMDNSAFAEPLENVEDAVNEGLEIVRGRLQNAGLNVTVNASFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAKRMGCVLMGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLTYFLVNFWKTNDLPFKTYSWSTSYVYKNGTESEDCFWYLNALEASVSYFSHELSFKLVLRQDKEFQDILMDHNRKSNVIVMCGDPQFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTQSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKTFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNQTNPVDMSPTFTWKNSKLPNDITDRGPQ

Approximately 60-75 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.