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  4. GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc)

GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc)

Cat. No.: HY-P77942
Handling Instructions

GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc) is the recombinant human-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc) is 407 a.a., with molecular weight of 85-115 kDa.

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Description

GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc) is the recombinant human-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc) is 407 a.a., with molecular weight of 85-115 kDa.

Background

GUCY2C, a guanylyl cyclase, serves as a catalyst in the synthesis of cyclic (cGMP) from GTP, as evidenced by studies. Additionally, this protein functions as a receptor for the E. coli heat-stable enterotoxin, where the enterotoxin significantly stimulates the accumulation of cin mammalian cells expressing GUCY2C. Furthermore, GUCY2C is activated by endogenous peptides, guanylin and uroguanylin. This multifaceted role underscores the intricate regulatory mechanisms involving GUCY2C in cellular signaling and its responsiveness to various stimuli.

Species

Human

Source

HEK293

Tag

C-hFc

Accession

P25092 (S24-Q430)

Gene ID
Molecular Construction
N-term
GUCY2C (S24-Q430)
Accession # P25092
hFc
C-term
Synonyms
Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL
Molecular Weight

85-115 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc)
Cat. No.:
HY-P77942
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