GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, N-His)

GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, N-His) is the recombinant human-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with N-10*His labeled tag.

GUCY2C, a guanylyl cyclase, serves as a catalyst in the synthesis of cyclic (cGMP) from GTP, as evidenced by studies. Additionally, this protein functions as a receptor for the E. coli heat-stable enterotoxin, where the enterotoxin significantly stimulates the accumulation of cin mammalian cells expressing GUCY2C. Furthermore, GUCY2C is activated by endogenous peptides, guanylin and uroguanylin. This multifaceted role underscores the intricate regulatory mechanisms involving GUCY2C in cellular signaling and its responsiveness to various stimuli.

Human

HEK293

N-10*His

P25092 (S24-Q430)

2984  [NCBI]

Extracellular Domain

SQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQ

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.