H2-D1 Protein, Mouse (His-SUMO)
Based on 1 Customer Validation
The H2-D1 protein is a key element of the immune system and is actively involved in the presentation of foreign antigens. As a major histocompatibility complex class I (MHC-I) component, H2-D1 forms a heterodimer with α and β chains and is essential for recognizing and presenting antigen to cytotoxic T cells. H2-D1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived H2-D1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The H2-D1 protein is a key element of the immune system and is actively involved in the presentation of foreign antigens. As a major histocompatibility complex class I (MHC-I) component, H2-D1 forms a heterodimer with α and β chains and is essential for recognizing and presenting antigen to cytotoxic T cells. H2-D1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived H2-D1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
Background
The H2-D1 Protein plays a crucial role in the immune system by participating in the presentation of foreign antigens. As a key component of the major histocompatibility complex class I (MHC-I), H2-D1 forms a heterodimer with an alpha chain and a beta chain (beta-2-microglobulin). This complex is essential for the recognition and presentation of antigens to cytotoxic T cells, contributing to the surveillance and defense mechanisms of the immune system. Through its involvement in antigen presentation, H2-D1 plays a vital role in the orchestration of immune responses, facilitating the identification and elimination of foreign entities by the adaptive immune system.
Technical Parameters
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Species Mouse
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Source E. coli
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Tag N-His;N-SUMO
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Accession
P01900 (G25-T311)
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Gene ID14964
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Molecular Construction
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N-term
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6*His-SUMO
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H2-D1 (G25-T311)
Accession # P01900 -
C-term
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Protein Length
Extracellular Domain
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Synonyms
H-2 class I histocompatibility antigen; H-2D(D)
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AA Sequence
GSHSLRYFVTAVSRPGFGEPRYMEVGYVDNTEFVRFDSDAENPRYEPRARWIEQEGPEYWERETRRAKGNEQSFRVDLRTALRYYNQSAGGSHTLQWMAGCDVESDGRLLRGYWQFAYDGCDYIALNEDLKTWTAADMAAQITRRKWEQAGAAERDRAYLEGECVEWLRRYLKNGNATLLRTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQEMELVETRPAGDGTFQKWASVVVPLGKEQKYTCHVEHEGLPEPLTLRWGKEEPPSSTKTNT
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Molecular Weight
Approximately 50-54 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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