HAAO Protein, Human (sf9, His-GST)

HAAO proteins play a key role in cellular metabolism, catalyzing the oxidative ring-opening of 3-hydroxyanthranilic acid.This leads to the formation of 2-amino-3-carboxymuconic acid semialdehyde, which spontaneously cyclizes to quinolinic acid.HAAO Protein, Human (sf9, His-GST) is the recombinant human-derived HAAO protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

The HAAO protein assumes a critical role in cellular metabolism by catalyzing the oxidative ring opening of 3-hydroxyanthranilate, leading to the formation of 2-amino-3-carboxymuconate semialdehyde, which subsequently undergoes spontaneous cyclization to generate quinolinate. This enzymatic process is integral to the catabolism of tryptophan and contributes to the production of quinolinate, a compound involved in various biological pathways. The functionality of the HAAO protein in mediating these biochemical reactions highlights its importance in regulating the metabolic fate of 3-hydroxyanthranilate and underscores its broader significance in cellular homeostasis.

Human

Sf9 insect cells

C-His;N-GST

P46952 (M1-G286)

23498  [NCBI]

Full Length

MERRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGEEVFYQLEGDMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVVERRRLETELDGLRYYVGDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEPMSLDAWLDSHHRELQAGTPLSLFGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVTMGGRRLSLAPDDSLLVLAGTSYAWERTQGSVALSVTQDPACKKPLG

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.