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  3. HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc)

HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc)

Cat. No.: HY-P76980
Handling Instructions

The gB Protein is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB Protein interacts with heparin sulfate proteoglycan and forms an association with gH/gL heterodimer. HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc) is the recombinant Virus-derived HCMV Glycoprotein B/gB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc) is 676 a.a., with molecular weight of 135-145 kDa.

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Description

The gB Protein is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB Protein interacts with heparin sulfate proteoglycan and forms an association with gH/gL heterodimer. HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc) is the recombinant Virus-derived HCMV Glycoprotein B/gB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc) is 676 a.a., with molecular weight of 135-145 kDa.

Background

gB is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB is involved in initial attachment through a gM/gN complex bound to heparin sulfate, which binds heparin with higher affinity. gB plays a key role in the fusion of viruses and cell membranes, facilitating the entry of viruses into host cells. The complex fusion mechanisms required for this process include at least gB and gH/gL heterodimers. gB interacts with host integrins ITGB1, PDGFRA, and EGFR, possibly entering the receptor as post-attachment[1][2][3].

Species

Virus

Source

HEK293

Tag

C-hFc

Accession

AAA45920 (S25-K700, with cleavage site mutated RTKR to TTQT)

Gene ID

/

Molecular Construction
N-term
HCMV gB (S25-K700, cleavage site mutated)
Accession # AAA45920
hFc
C-term
Synonyms
Human cytomegalovirus (HCMV) Glycoprotein B / gB Protein (ECD, Fc)
Molecular Weight

135-145 kDa

Purity

Greater than 80% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc)
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HY-P76980
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