HA/Hemagglutinin Protein, H11N2 (AAY85533, HEK293, His)

HA/Hemagglutinin Protein is a type of viral fusion protein. It mediates the fusion of the membrane of endocytosed virus particles with the endosomal membrane, responsible for the penetration of the virus into the cytoplasm. HA/Hemagglutinin Protein binds to sialic acid receptors, allowing the virus particles to attach to cells. HA/Hemagglutinin Protein is a homotrimer consisting of a globular head domain located at the top of the stem domain near the membrane. Hemagglutinin/HA Protein, H11N2 (AAY85533, HEK293, His) is the recombinant Virus-derived Hemagglutinin/HA protein, expressed by HEK293 , with C-His labeled tag.

HA/Hemagglutinin Protein is a type of viral fusion protein that mediates the fusion of the membrane of endocytosed virus particles with the endosome membrane, responsible for penetrating the virus into the cytoplasm. The membrane fusion mediated by HA/Hemagglutinin Protein occurs in vivo and depends on the pH value in vivo. The acidic environment in vivo triggers conformational changes in HA/Hemagglutinin Protein, which in turn induces virus-host membrane fusion. HA/Hemagglutinin Protein binds to sialic acid receptors, allowing the virus particles to attach to cells. HA/Hemagglutinin Protein is a homotrimer consisting of a globular head domain located at the top of the membrane proximal stalk domain^[1][2].

Virus

HEK293

C-His

AAY85533 (D17-K528)

/

Partial

DEICIGYLSNNSTDKVDTIIENNVTVTSSVELVETEHTGSFCSINGKQPISLGDCSFAGWILGNPMCDDLIGKTSWSYIVEKPNPTNGICYPGILENEEELRLKFSGVLEFNKFEAFTSNGWGAVNSGAGVTAACKFGSSNSFFRNMIWLIHQSGTYPVIKRTFNNTKGRDVLVVWGIHHPATLKEHQDLYKKDSSYVAVGSETYNRRFTPEISTRPKVNGQAGRMTFYWTIVKPGESITFESNGAFLAPRYAFEIVSVGNGKLFRSELNIESCSTKCQTEVGGINTNKSFHSVHRNTIGDCPKYVNVKSLKLATGLRNVPAIASRGLFGAIAGFIEGGWPGLINGWYGFQHRNEEGTGIAADKESTQKAIDQITSKVNNIVDRMNTNFESVQHEFSEIEERINRLSKHVDDSVVDIWSYNAQLLVLLENEKTLDLHDSNVRNLHERVRRMLKDNAKDEGNGCFTFYHKCDNECIEKVRNGTYDHKEFEKESKINRQEIEGVKLDSSGNVYK

Approximately 70 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Bosch F X, et al. The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses[J]. Virology, 1979, 95(1): 197-207.  [Content Brief]

  [2]. Wu N C, et al. Influenza hemagglutinin structures and antibody recognition[J]. Cold Spring Harbor perspectives in medicine, 2020, 10(8): a038778.  [Content Brief]