Hemagglutinin-neuraminidase Protein, HPIV-4b (sf9, His)

Hemagglutinin-neuraminidase is a single viral protein that has both hemagglutinin and neuraminidase activities. Hemagglutinin neuraminidase protein plays a key role in viral infection. It attaches the virus to a cell receptor containing sialic acid, initiating the infection process. Hemagglutinin-neuraminidase Protein, HPIV-4b (sf9, His) is the recombinant Virus-derived Hemagglutinin-neuraminidase protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Hemagglutinin-neuraminidase Protein, HPIV-4b (sf9, His) is 532 a.a., with molecular weight of ~57.12 KDa.

Hemagglutinin-neuraminidase is a single viral protein that has both hemagglutinin and neuraminidase activities. Hemagglutinin neuraminidase protein plays a key role in viral infection. It attaches the virus to a cell receptor containing sialic acid, initiating the infection process. When the hemagglutinin-neuraminidase protein binds to the receptor, it causes conformational changes that allow the F protein to trigger fusion between the virion and the cell membrane. This fusion event facilitates the entry of the virus into the host cell. In addition, the hemagglutinin-neuraminidase protein exhibits neuraminidase activity, which contributes to the effective transmission of the virus. By separating mature virions from glycoproteins containing neuraminidase, the hemagglutinin-neuraminidase protein enables the virus to reproduce efficiently^[1][2][3].

Virus

Sf9 insect cells

N-His

ARB07730 (S48-The579)

/

Approximately 57.12 kDa.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.