HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His-Avi)

The HLA-A*0201 HPV16 E7 complex, part of the MHCI family, is central to immune recognition. Associated with β2 microglobulin, it presents viral and tumor peptides on antigen-presenting cells for CD8-positive T cell recognition. This interaction guides antigen-specific T cell responses against infected or transformed cells. The complex's diverse repertoire includes self-peptides and varies in peptide length, contributing to antigen specificity. HLA-A*0201, representing this complex, presents viral and tumor-associated epitopes, highlighting its pivotal role in immune responses against pathogens and cancer. HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-A*0201 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and YMLDLQPET peptide. HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His-Avi), has molecular weight of 53-63 kDa.

The HLA-A*0201 HPV16 E7 complex, a member of the antigen-presenting major histocompatibility complex class I (MHCI) family, plays a pivotal role in immune recognition and response. When associated with β2 microglobulin (B2M), it presents predominantly viral and tumor-derived peptides on the surface of antigen-presenting cells, facilitating recognition by CD8-positive T cells through their alpha-beta T cell receptors (TCR). This interaction guides an antigen-specific T cell immune response, crucial for eliminating infected or transformed cells. Beyond viral peptides, it may also present self-peptides originating from the signal sequence of secreted or membrane proteins. The complex displays a diverse repertoire of intracellular peptide antigens, typically 8 to 13 amino acids in length, processed through immunoproteasomes or insulin-degrading enzyme. The binding of different peptides, defined by specific anchor residues, contributes to the fine specificity of antigen recognition. Notably, HLA-A*0201, a representative allele, presents a restricted peptide repertoire, including viral epitopes from influenza and SARS-CoV-2, as well as tumor-associated antigens such as MAGE1, MAGEA3, and WT1. The complexity of peptide presentation highlights the crucial role of this MHCI complex in orchestrating immune responses against various pathogens and cancerous cells.

Human

HEK293

C-Avi;C-His

P04439-1 (G25-T305)&P61769 (I21-M119)&YMLDLQPET

/&567

53-63 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.