HLA-C*0304 KRAS G12D Complex Protein, Human (Biotinylated, GADGVGKSAL, HEK293, His-Avi)

The HLA-C*0304 KRAS G12D Complex, a major histocompatibility complex class I (MHCI) molecule, plays crucial roles in reproduction and antiviral immunity. Teaming up with B2M, it presents self and viral peptides, acting as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) on NK cells. In allogeneic contexts, it facilitates trophoblast interactions with NK cells, crucial for placental development. During viral infections, HLA-C*0304 may disrupt KIR-mediated inhibition and promote infected cell lysis. In adaptive immunity, it presents viral peptides to CD8-positive T cells, contributing to antigen-specific T cell responses in chronic viral infections. HLA-C*0304's fine specificity for antigen recognition and its role in immune surveillance stem from its ability to recognize diverse peptides and specific MHC residues. HLA-C*0304 KRAS G12D Complex Protein, Human (Biotinylated, GADGVGKSAL, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-C*0304 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and GADGVGKSAL peptide. HLA-C*0304 KRAS G12D Complex Protein, Human (Biotinylated, GADGVGKSAL, HEK293, His-Avi), has molecular weight of 55-65 kDa.

HLA-C*0304, an antigen-presenting major histocompatibility complex class I (MHCI) molecule, plays a pivotal role in reproduction and antiviral immunity. In association with B2M/beta 2 microglobulin, it exhibits a specific range of self and viral peptides, serving as a dominant ligand for both inhibitory and activating killer immunoglobulin receptors (KIRs) on NK cells. Particularly crucial in an allogeneic context, such as during pregnancy, HLA-C*0304 facilitates the interaction between extravillous trophoblasts and uterine NK cells expressing KIRs, regulating trophoblast invasion essential for placentation and overall fetal growth. During viral infections, HLA-C*0304 may present viral peptides with low affinity for KIRs, disrupting KIR-mediated inhibition through peptide antagonism and promoting the lysis of infected cells. In the realm of adaptive immunity, HLA-C*0304 presents a restricted repertoire of viral peptides to CD8-positive T cells, enabling antigen-specific T cell immune responses against infected cells, particularly in chronic viral infections like HIV-1 or CMV. The binding of peptides with allele-specific motifs, defined by anchor residues at positions 2 and 9, showcases HLA-C*0304's ability to recognize diverse peptide antigens arising from cytosolic proteolysis via the proteasome. The peptide's fine specificity for antigen recognition and MHC residues accounting for T cell MHC restriction collectively contribute to HLA-C*0304's role in immune surveillance.

Human

HEK293

C-Avi;C-His

QAV56463.1 (G25-T305)&P61769 (I21-M119)&GADGVGKSAL

/&567

55-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.