HPRG Protein, Rat (HEK293, His)

Heparin-binding protein (HPRG) is a versatile plasma glycoprotein regulating immune processes, cell adhesion, and angiogenesis. It binds ligands like heparin and thrombospondins, modulates phagocytosis, and interacts with proteins including HPSE, TMP1, and PLG, influencing diverse cellular functions. HPRG Protein, Rat (HEK293, His) is the recombinant rat-derived HPRG protein, expressed by HEK293 , with C-His labeled tag.

Heparin-binding protein (HPRG) is a versatile plasma glycoprotein known for its ability to bind various ligands, including heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Functioning as an adapter protein, HPRG is implicated in the regulation of diverse physiological processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation, and fibrinolysis. Its involvement extends to mediating the clearance of necrotic cells through an enhanced phagocytosis pathway, dependent on heparan sulfate. This process is subject to modulation by specific HPRG ligands, including heparin and zinc ions. HPRG exhibits affinity for IgG subclasses of immunoglobulins with kappa and lambda light chains, playing a regulatory role in their clearance and inhibiting the formation of insoluble immune complexes. Moreover, HPRG tethers plasminogen to cell surfaces and interacts with T-cells, influencing their morphology. Notably, it modulates angiogenesis by counteracting the antiangiogenic effect of thrombospondins, specifically THBS1 and THBS2, through interactions with CD36. Additionally, HPRG engages in interactions with various proteins, including HPSE, TMP1, F12, PLG, and TPM1, contributing to its involvement in diverse cellular and molecular processes.

Rat

HEK293

C-His

Q99PS8 (L19-K525)

171016  [NCBI]

Full Length of Mature Protein

LSPTNCDASKPLAEKVLDLINKGRRSGYTFQLLRVSDAHLDRVETATIYYLVLDVVESDCWVLSTKAQDECLPAMRTSEVVIGQCKVIATRYSNESQDLSVNGYNCTMRSVSSAYINTKDSPVLVDSFEDSEPYRKLARKALDKYKAENGDFASFRVERAERVIRMRGGERTSYFIEFSVRNCSTQHFPRHPPVFGLCRVVLTYSTEASDLETPEYTDLICEVFNTEDLKNRSDMKPHRGHEHPHCDKHLCKLSGPRDHHHTHKTHEIGCPPPPEGKDNSDRPPLQEGALPQMLPGHSGPSGTNRSHRPPHNHSCNEHPCHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGHHPHGDHPHGHHPHGHDFLDYGPCDPPSNSQELKGQYHRGHGPPHGHSRKRGPGKGLFPFHQRQIGYVYRLPPLNVGEVLTPPEANFPIFSLPNCNRPPQPEIRPFPQTASKSCPGKFEGKFPQVSNFFEHTPPK

Approximately 58.6 kDa.

≥ 90%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.