HRH3-VLPs Protein, Human (HEK293, His)

HRH3-VLPs protein, part of the H3 subclass of histamine receptors, potentially mediates histamine signals in the CNS and peripheral nervous system. It inhibits adenylate cyclase, showing constitutive activity even without agonists. Notably, isoform 3 stimulation does not affect adenylate cyclase activity or induce intracellular calcium mobilization. HRH3-VLPs Protein, Human (HEK293, His) is the recombinant human-derived HRH3-VLPs protein, expressed by HEK293 , with C-10*His labeled tag. The total length of HRH3-VLPs Protein, Human (HEK293, His) is 445 a.a., with molecular weight of 50.0 kDa.

The HRH3-VLPs protein belongs to the H3 subclass of histamine receptors, playing a potential role in mediating histamine signals within the central nervous system (CNS) and peripheral nervous system. It operates by inhibiting adenylate cyclase and exhibits notable constitutive activity, demonstrating spontaneous activity even in the absence of agonists. Interestingly, stimulation of isoform 3 fails to alter adenylate cyclase activity or induce intracellular calcium mobilization.

Human

HEK293

C-10*His

Q9Y5N1 (M1-K445)

11255

MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK

50.0 kDa

/

<1 EU/μg, determined by LAL method.