ITPase Protein, Human (His)
ITPase protein is a pyrophosphatase that is essential in nucleotide metabolism and can hydrolyze non-classical purine nucleotides such as ITP, dITP, dHAPTP and XTP into their respective monophosphate derivatives. It lacks distinction between deoxy and ribose forms. ITPase Protein, Human (His) is the recombinant human-derived ITPase protein, expressed by E. coli , with C-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
ITPase protein is a pyrophosphatase that is essential in nucleotide metabolism and can hydrolyze non-classical purine nucleotides such as ITP, dITP, dHAPTP and XTP into their respective monophosphate derivatives. It lacks distinction between deoxy and ribose forms. ITPase Protein, Human (His) is the recombinant human-derived ITPase protein, expressed by E. coli , with C-6*His labeled tag.
Background
ITPase, a pyrophosphatase, plays a pivotal role in nucleotide metabolism by hydrolyzing non-canonical purine nucleotides, including inosine triphosphate (ITP), deoxyinosine triphosphate (dITP), 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP), and xanthosine 5'-triphosphate (XTP), into their respective monophosphate derivatives. This enzyme demonstrates a lack of discrimination between deoxy- and ribose forms. The primary function of ITPase is presumed to be the exclusion of non-canonical purines from RNA and DNA precursor pools. By preventing the incorporation of these purines into RNA and DNA, ITPase safeguards the integrity of genetic material, contributing to the maintenance of genomic stability and averting potential chromosomal lesions.
Technical Parameters
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Species Human
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Source E. coli
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Tag C-6*His
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Accession
Q9BY32-1 (A2-A194)
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Molecular Construction
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N-term
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ITPase (A2-A194)
Accession # Q9BY32-1 -
6*His
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C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
ITPA; Inosine Triphosphate Pyrophosphatase; Prev. C20orf37; Epididymis Secretory Sperm Binding Protein; Nucleoside-Triphosphate Diphosphatase; Inosine Triphosphate Pyrophosphohydrolase; XTP/DITP Diphosphatase; Nucleoside-Triphosphate Pyrophosphatase; HLC1
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AA Sequence
AASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLAA
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Predicted Molecular Mass
22.5 kDa
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Molecular Weight
Approximately 21 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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