Kallikrein-13 Protein, Human (HEK293, His)

Kallikrein-13 (KLK13) is a member of KLK family and is a secreted serine protease expressed in endocrine tissues, including the prostate, testis, breast, and ovary. Expression of KLK13 is regulated by steroid hormones and may be useful as a marker for breast cancer. KLK13 is also required for the human coronavirus HKU1 infection of human respiratory epithelial cells as a priming protease. Kallikrein-13 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-13 protein, expressed by HEK293, with C-6*His labeled tag. The total length of Kallikrein-13 Protein, Human (HEK293, His) is 246 a.a., with molecular weight of 28-38 kDa.

Kallikrein-13 (KLK13) is a member of KLK family and is a secreted serine protease expressed in endocrine tissues, including the prostate, testis, breast, and ovary. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. Expression of KLK13 is regulated by steroid hormones and may be useful as a marker for breast cancer. KLK13 is also required for the human coronavirus HKU1 infection of human respiratory epithelial cells as a priming protease^[1][2].

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

Q9UKR3 (G17-I262)

26085  [NCBI]

GGVSQESSKVLNTNGTSGFLPGGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEGLKVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETI

28-38 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, 10% Glycerol, pH 5.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.