2. Recombinant Proteins
  3. Cytokines and Growth Factors Biotinylated Proteins
  4. TGF-beta Superfamily Neurotrophic Factors
  5. Transforming Growth Factor-β TGF- β
  6. TGF-β3
  7. Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His)

Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His)

Cat. No.: HY-P701080
Handling Instructions

Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Latent TGF beta 3/Latent TGFB3 protein, expressed by HEK293 , with N-His labeled tag. The total length of Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His) is 389 a.a., with molecular weight of 43-48 kDa & 50-60 kDa, respectively.

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Description

Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Latent TGF beta 3/Latent TGFB3 protein, expressed by HEK293 , with N-His labeled tag. The total length of Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His) is 389 a.a., with molecular weight of 43-48 kDa & 50-60 kDa, respectively.
Background

Latent Transforming growth factor beta-3 (TGF-beta-3) proprotein serves as the precursor for both the Latency-associated peptide (LAP) and the active TGF-beta-3 chains, acting as the regulatory and functional subunits, respectively. It plays a vital role in maintaining the latent state of TGF-beta-3 within the extracellular matrix. Through non-covalent association with TGF-beta-3, Latent TGF-beta-3 actively regulates the activation process by interacting with key 'milieu molecules' such as LTBP1 and LRRC32/GARP. These interactions contribute to the controlled activation of TGF-beta-3, with LTBP1 and LRRC32/GARP acting as crucial components in this regulatory mechanism. Additionally, interaction with integrins induces structural changes in the Latency-associated peptide chain, leading to the subsequent release of active TGF-beta-3. This sophisticated molecular interplay underscores the pivotal role of Latent TGF-beta-3 in orchestrating the regulated activation of TGF-beta-3 in various physiological contexts.
Species

Human
Source

HEK293
Tag

N-His
Accession

P10600-1 (L24-S412)
Gene ID

/
Molecular Construction
N-term
His
TGFB3 (L24-S412)
Accession # P10600-1
C-term
Synonyms
TGFB3; ARVD; TGF-beta3; TGF-β; TGFβ3; TGFβ
Molecular Weight

43-48 kDa & 50-60 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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