2. Recombinant Proteins
  3. Receptor Proteins
  4. Leukocyte Immunoglobin-like Receptors
  5. LIR-1
  6. LILRB1/CD85j/ILT2 Protein, Rhesus macaque (440a.a, HEK293, Fc)

LILRB1/CD85j/ILT2 Protein, Rhesus macaque (440a.a, HEK293, Fc)

Cat. No.: HY-P78325
Handling Instructions

LILRB1/CD85j/ILT2 Protein is an inhibitory receptor broadly expressed on leukocytes and recognizes HLA-class I and human cytomegalovirus UL18. LILRB1/CD85j/ILT2 Protein, Rhesus macaque (440a.a, HEK293, Fc) is the recombinant Rhesus Macaque-derived LILRB1/CD85j/ILT2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LILRB1/CD85j/ILT2 Protein, Rhesus macaque (440a.a, HEK293, Fc) is 440 a.a., with molecular weight of 80-90 kDa.

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Description

LILRB1/CD85j/ILT2 Protein is an inhibitory receptor broadly expressed on leukocytes and recognizes HLA-class I and human cytomegalovirus UL18[1]. LILRB1/CD85j/ILT2 Protein, Rhesus macaque (440a.a, HEK293, Fc) is the recombinant Rhesus Macaque-derived LILRB1/CD85j/ILT2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LILRB1/CD85j/ILT2 Protein, Rhesus macaque (440a.a, HEK293, Fc) is 440 a.a., with molecular weight of 80-90 kDa.
Background

LILRB1/CD85j/ILT2 Protein a member of the leukocyte immunoglobulin-like receptor (LIR) family which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs)[2]. LILRB1/CD85j/ILT2 Protein is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity[3].
Species

Rhesus Macaque
Source

HEK293
Tag

C-hFc
Accession

F7H3G7 (S17-H456)
Gene ID

692340  [NCBI]
Molecular Construction
N-term
LILRB1 (S17-H456)
Accession # F7H3G7
hFc
C-term
Synonyms
ILT2; ILT-2; ILT2FLJ37515; LILRB1; LIR1; MIR7; CD85J; XXbac-BCX85G21.4
Molecular Weight

80-90 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

LILRB1/CD85j/ILT2 Protein, Rhesus macaque (440a.a, HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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LILRB1/CD85j/ILT2 Protein, Rhesus macaque (440a.a, HEK293, Fc)
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