2. Recombinant Proteins
  3. Receptor Proteins
  4. NKp46/NCR1 Protein, Cynomolgus (HEK293, hFc)

NKp46/NCR1 Protein, Cynomolgus (HEK293, hFc)

Cat. No.: HY-P701075
Handling Instructions

NKp46/NCR1 Protein, a pivotal cytotoxicity-activating receptor, enhances the efficiency of activated natural killer (NK) cells in destroying tumor cells. It interacts with CD3Z and FCER1G, potentially amplifying NK cell recognition and targeted lysis of cancerous cells. NKp46/NCR1 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived NKp46/NCR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKp46/NCR1 Protein, Cynomolgus (HEK293, hFc) is 233 a.a., with molecular weight of 60-70 kDa.

For research use only. We do not sell to patients.

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Description

NKp46/NCR1 Protein, a pivotal cytotoxicity-activating receptor, enhances the efficiency of activated natural killer (NK) cells in destroying tumor cells. It interacts with CD3Z and FCER1G, potentially amplifying NK cell recognition and targeted lysis of cancerous cells. NKp46/NCR1 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived NKp46/NCR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKp46/NCR1 Protein, Cynomolgus (HEK293, hFc) is 233 a.a., with molecular weight of 60-70 kDa.
Background

NKp46/NCR1 Protein is a cell receptor that plays a crucial role in enhancing the efficiency of activated natural killer (NK) cells in destroying tumor cells. It acts as a cytotoxicity-activating receptor, potentially aiding in the process of tumor cell lysis by NK cells. NKp46/NCR1 Protein interacts with CD3Z and FCER1G, which may further enhance the ability of NK cells to recognize and target cancerous cells.
Species

Cynomolgus
Source

HEK293
Tag

C-hFc
Accession

Q95JB9 (P22-N254)
Gene ID

102115479  [NCBI]
Molecular Construction
N-term
NKp46 (P22-N254)
Accession # Q95JB9
hFc
C-term
Synonyms
CD335; Ly94; NCR1; NKp46; MAR-1; NKP46FLJ99094
Molecular Weight

60-70 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

NKp46/NCR1 Protein, Cynomolgus (HEK293, hFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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