NKp46/NCR1 Protein, Cynomolgus (HEK293, His)

NKp46/NCR1 Protein, a pivotal cytotoxicity-activating receptor, enhances the efficiency of activated natural killer (NK) cells in destroying tumor cells. It interacts with CD3Z and FCER1G, potentially amplifying NK cell recognition and targeted lysis of cancerous cells. NKp46/NCR1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived NKp46/NCR1 protein, expressed by HEK293 , with C-His labeled tag.

NKp46/NCR1 Protein is a cell receptor that plays a crucial role in enhancing the efficiency of activated natural killer (NK) cells in destroying tumor cells. It acts as a cytotoxicity-activating receptor, potentially aiding in the process of tumor cell lysis by NK cells. NKp46/NCR1 Protein interacts with CD3Z and FCER1G, which may further enhance the ability of NK cells to recognize and target cancerous cells.

Immobilized Cynomolgus NKp46, His Tag at 0.5 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-NKp46 Antibody, hFc Tag with the EC₅₀ of ≤7.0 ng/mL determined by ELISA.

Cynomolgus

HEK293

C-8*His

Q95JB9 (P22-N254)

102115479  [NCBI]

Extracellular Domain

PKQTLPKPIIRAESTYMVPKEKQATLCCQGSYGAVEYQLHFEGSLFAVERPKPPERINGVKFHIPDMNSRKAGRYSCIYRVGELWSERSDLLDLVVTEMYDTPTLSVHPGPEVTSGEKVTFYCRLDTATSMFLLLKEGRSRDVQRSYGKVQAEFPMGPVTTAHRGSYRCFGSYNNYAWSFPSEPVKLLVTGDIENTSLAPTDPTFPDSWDTCLLTRETGLQKDLALWDHTAQN

35-45 kDa

≥ 95%, as determined by Bis-Tris PAGE.

Lyophilized powder

1.Lyophilized from a 0.22 μm filtered solution of 20 mM Tris, 150 mM NaCl, 100 mM L-arginine, pH 8.2, 8% trehalose.
2.Lyophilized from a 0.22 μm filtered solution of PBS, 8% trehalose, pH 7.4.
Please refer to the lot-specific COA for specific buffer information.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.