NKp46/NCR1 Protein, Rat (HEK293, Fc)

The NKp46/NCR1 protein is a key cytotoxic activating receptor that increases the efficiency of activated natural killer (NK) cells, particularly in targeting tumor cell lysis. Through interactions with CD3Z and FCER1G, NKp46/NCR1 orchestrates important connections that enhance the ability of NK cells to destroy tumor cells. NKp46/NCR1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived NKp46/NCR1 protein, expressed by HEK293 , with C-hFc labeled tag.

As a cytotoxicity-activating receptor, NKp46/NCR1 stands at the forefront of natural killer (NK) cell functionality, potentially bolstering the efficacy of activated NK cells in the targeted lysis of tumor cells. This receptor, instrumental in mediating the cytotoxicity response, engages with CD3Z and FCER1G, thereby orchestrating essential interactions that enhance the NK cell's capacity for tumor cell destruction. The intricate interplay between NKp46/NCR1 and its associated proteins underscores its pivotal role in regulating and augmenting the cytotoxic functions of activated NK cells, positioning it as a key player in immune surveillance and antitumor immunity.

Measured by its binding ability in a functional ELISA. Immobilized Rat NKp46 at 0.5 µg/mL can bind Human Vimentin. The ED₅₀ for this effect is 123.5 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Rat NKp46 at 0.5 µg/mL can bind Human Vimentin. The ED₅₀ for this effect is 123.5 ng/mL.

Rat

HEK293

C-hFc

Q9Z0H5 (Q17-N255)

117547  [NCBI]

Extracellular Domain

QRINTEKQTLPKPIIWAKPSIMVTKGNSVNIWCQGAQSASEYQLYFEGSFFALERPKSSRSMNKVKFFISQMTSHTAGIYTCFYQSGELWSESSNPLKLVVTGLYDTPTLWVHPGPEVTLGENVTFSCHLKTATSKFFLLKERESNHIQHKYGNIQAEFPMGPVTRAHRGTYRCFGSYNDYAWSFPSEPVTLLITGEVENTSLAPTDPVSSLDYWEFDLSTKESGLQKDSAFWDHTAQN

Approximately 60-75 kDa due to the glycosylation.

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  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.