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p53 Protein, Cynomolgus

Cat. No.: HY-P74657
Handling Instructions

p53 protein, a tumor suppressor, induces growth arrest or apoptosis in various tumors, regulating cell division through gene control, including cyclin-dependent kinase inhibitors. It stimulates BAX and FAS antigen expression or represses Bcl-2 to induce apoptosis. p53's multifaceted role underscores its importance in orchestrating cellular responses, maintaining genomic integrity, and countering aberrant cell proliferation. p53 Protein, Cynomolgus is the recombinant cynomolgus-derived p53 protein, expressed by E. coli, with tag free. The total length of p53 Protein, Cynomolgus is 393 a.a., with molecular weight of ~48 kDa.

For research use only. We do not sell to patients.

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Description

p53 protein, a tumor suppressor, induces growth arrest or apoptosis in various tumors, regulating cell division through gene control, including cyclin-dependent kinase inhibitors. It stimulates BAX and FAS antigen expression or represses Bcl-2 to induce apoptosis. p53's multifaceted role underscores its importance in orchestrating cellular responses, maintaining genomic integrity, and countering aberrant cell proliferation. p53 Protein, Cynomolgus is the recombinant cynomolgus-derived p53 protein, expressed by E. coli, with tag free. The total length of p53 Protein, Cynomolgus is 393 a.a., with molecular weight of ~48 kDa.

Background

p53 protein functions as a tumor suppressor in numerous tumor types, exerting its effects through the induction of growth arrest or apoptosis depending on the physiological conditions and cell type. In the realm of cell cycle regulation, p53 acts as a trans-activator that negatively regulates cell division by overseeing a set of genes crucial for this process, including an inhibitor of cyclin-dependent kinases. Apoptosis induction by p53 is thought to occur through the stimulation of BAX and FAS antigen expression or repression of Bcl-2 expression. The multifaceted role of p53 underscores its significance in orchestrating cellular responses to maintain genomic integrity and counteract aberrant cell proliferation.

Species

Cynomolgus

Source

E. coli

Tag

Tag Free

Accession

E3U906 (M1-D393)

Gene ID
Molecular Construction
N-term
p53 (M1-D393)
Accession # E3U906
C-term
Synonyms
Cellular tumor antigen p53; TP53; Antigen NY-CO-13
Molecular Weight

Approximately 48 kDa

Purity

Greater than 80% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

p53 Protein, Cynomolgus Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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p53 Protein, Cynomolgus
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HY-P74657
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