PIK3R3 Protein, Human (sf9, His, GST)

Cat. No.: HY-P701744: Data Sheet
COA

SDS
Handling Instructions
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PIK3R3 protein, through its SH2 domain, interacts with phosphorylated protein-tyrosine kinases, crucially regulating their kinase activity. During insulin stimulation, PIK3R3 binds to IRS-1. Operating as a heterodimer with a p110 catalytic subunit, it interacts with AXL, expanding its functional network. PIK3R3 Protein, Human (sf9, His, GST) is the recombinant human-derived PIK3R3 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

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Surface Plasmon Resonance (SPR) Assay Service Protein Expression Service

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10 μg	해외재고보유	Estimated Time of Arrival: December 31
50 μg	해외재고보유	Estimated Time of Arrival: December 31
100 μg	견적 받기

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1 Publications Citing Use of MCE PIK3R3 Protein, Human (sf9, His, GST)

•Gut Microbes. 2025 Dec;17(1):2486515. [Abstract]

Biological Activity
Technical Parameters
Properties
제품 설명

제품 설명	PIK3R3 protein, through its SH2 domain, interacts with phosphorylated protein-tyrosine kinases, crucially regulating their kinase activity. During insulin stimulation, PIK3R3 binds to IRS-1. Operating as a heterodimer with a p110 catalytic subunit, it interacts with AXL, expanding its functional network. PIK3R3 Protein, Human (sf9, His, GST) is the recombinant human-derived PIK3R3 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.
Background	The PIK3R3 protein engages with activated (phosphorylated) protein-tyrosine kinases via its SH2 domain, playing a pivotal role in modulating their kinase activity. Additionally, during insulin stimulation, PIK3R3 forms a binding association with IRS-1. This protein operates as a heterodimer, comprising a regulatory subunit (PIK3R3) and a p110 catalytic subunit (PIK3CA, PIK3CB, or PIK3CD). Furthermore, PIK3R3 demonstrates interaction with AXL, contributing to its functional network.
Species	Human
Source	Sf9 insect cells
Tag	N-8*His;N-GST
Accession	Q92569 (Y2-R461)
Gene ID	8503
Molecular Construction	N-term 8*His-GST PIK3R3 (Y2-R461) Accession # Q92569 C-term
Protein Length	Partial
Synonyms	PIK3R3; Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK
AA Sequence	YNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
분자량	82.1 kDa
Purity	≥ 90%, as determined by reducing SDS-PAGE.
Appearance	Solution.
Formulation	Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5% glycerol, 1 mM DTT, 0.1 M trehalose. Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
Endotoxin Level	<1 EU/μg, determined by LAL method.
Reconstitution	Please use rapid thawing with running water to thaw the protein.
Storage & Stability	Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
선적	Shipping with dry ice.
각종 서류	Select Batch: Data Sheet (238 KB) SDS (252 KB) COA (220 KB) Handling Instructions (2659 KB)