Prolactin R Protein, Canine (HEK293, Fc)

Prolactin R protein serves as a receptor for the anterior pituitary hormone prolactin and significantly interacts with SMARCA1, NEK3, and VAV2. The latter two interactions are prolactin-dependent, emphasizing the role of the receptor in transducing prolactin-induced signals that are critical for multiple physiological processes, particularly in reproduction and lactation. Prolactin R Protein, Canine (HEK293, Fc) is the recombinant canine-derived Prolactin R protein, expressed by HEK293 , with C-hFc labeled tag.

The Prolactin R protein serves as a receptor for the anterior pituitary hormone prolactin. It engages in crucial interactions with SMARCA1, NEK3, and VAV2, with the latter two interactions being prolactin-dependent. These molecular associations underscore the receptor's role in transducing signals triggered by prolactin, a hormone central to various physiological processes, particularly those related to reproduction and lactation. The interactions with SMARCA1, NEK3, and VAV2 highlight the intricate regulatory network that orchestrates cellular responses in a prolactin-dependent manner.

Canine

HEK293

C-hFc

XP_038519869.1 (Q25-T235)

479363  [NCBI]

Partial

QSPPGKPEILKCRSPEKETFTCWWKPGDDGGLPTNYTLTYHKEGETLTHECPDYITSGPNSCYFNKKHTSIWTMYIITINATNQMGSSSSDPRYVDVTYIVEPDPPVNLTLELKQPEDKKPYLWMKWYPPTLVDVRSGWLTLQYEIRLKPKKATEWETHFAGQQTQFKILSLYPGQKYLVQVRCKPDHGFWSEWSPESSIQIPNDVTMKDT

Approximately 65-70 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.