REG-3 alpha/REG3A Protein, Rat (HEK293, Fc)

REG-3 alpha/REG3A Protein, a bactericidal C-type lectin lacking the EPN motif, functions as a hormone responding to stimuli like IL17A and the gut microbiome. Secreted by various cell types, it activates receptor EXTL3, initiating cell-specific signaling pathways. Induced by IL17A in keratinocytes, it regulates proliferation and differentiation post-skin injury, inhibiting skin inflammation by suppressing IL6 and TNF. In the pancreas, REG-3 alpha/REG3A permeabilizes beta-cell membranes, stimulating proliferation. REG-3 alpha/REG3A Protein, Rat (HEK293, Fc) is the recombinant rat-derived REG-3 alpha/REG3A protein, expressed by HEK293, with C-hFc labeled tag. The total length of REG-3 alpha/REG3A Protein, Rat (HEK293, Fc) is 174 a.a., with molecular weight of ~44 kDa.

REG-3 alpha/REG3A Protein is a bactericidal C-type lectin that lacks the EPN motif, which may explain its inability to bind peptidoglycan. It functions as a hormone in response to various stimuli, including anti-inflammatory signals like IL17A and the gut microbiome. REG-3 alpha/REG3A protein is secreted by different cell types and activates its receptor EXTL3, initiating cell-specific signaling pathways. In keratinocytes, it is induced by IL17A and plays a role in regulating keratinocyte proliferation and differentiation following skin injury. It also inhibits skin inflammation by suppressing inflammatory cytokines like IL6 and TNF. In the pancreas, REG-3 alpha/REG3A protein is able to permeabilize beta-cell membranes and stimulate their proliferation.

Rat

HEK293

C-hFc

P35231 (M1-Q174)

171162  [NCBI]

Approximately 44 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.