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  4. RGM-C Protein, Cynomolgus (HEK293, His)

RGM-C Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P701035
Handling Instructions

RGM-C Protein, a BMP coreceptor, crucially modulates BMP signaling and regulates hepcidin (HAMP) expression, impacting iron homeostasis. It interacts with BMP2, BMP4, BMP6, BMPR1B, and TMPRSS6, forming a molecular network that collectively mediates BMP-related signaling pathways and iron regulation. RGM-C Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived RGM-C protein, expressed by HEK293 , with C-His labeled tag. The total length of RGM-C Protein, Cynomolgus (HEK293, His) is 366 a.a., with molecular weight of 50-60 kDa & 30-40 kDa & 20-25 kDa, respectively.

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Description

RGM-C Protein, a BMP coreceptor, crucially modulates BMP signaling and regulates hepcidin (HAMP) expression, impacting iron homeostasis. It interacts with BMP2, BMP4, BMP6, BMPR1B, and TMPRSS6, forming a molecular network that collectively mediates BMP-related signaling pathways and iron regulation. RGM-C Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived RGM-C protein, expressed by HEK293 , with C-His labeled tag. The total length of RGM-C Protein, Cynomolgus (HEK293, His) is 366 a.a., with molecular weight of 50-60 kDa & 30-40 kDa & 20-25 kDa, respectively.
Background

RGM-C operates as a bone morphogenetic protein (BMP) coreceptor, contributing to the modulation of BMP signaling and playing a crucial role in the regulation of hepcidin (HAMP) expression, thereby influencing iron homeostasis. This protein interacts with BMP2, BMP4, BMP6, BMPR1B, and TMPRSS6, forming a network of molecular associations that collectively contribute to its role in mediating BMP-related signaling pathways and iron regulation.
Species

Cynomolgus
Source

HEK293
Tag

C-His
Accession

XP_005542141.1 (Q36-D401)
Gene ID

102138915  [NCBI]
Molecular Construction
N-term
RGM-C (Q36-D401)
Accession # XP_005542141.1
His
C-term
Synonyms
Hemojuvelin; Rgmc; DL-M; HFE2; HFE2AMGC23953; HJV; JH; RGMC; RGM-C
Molecular Weight

50-60 kDa & 30-40 kDa & 20-25 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

RGM-C Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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