SCG3/Secretogranin-3 Protein, Mouse (HEK293, His)

SCG3/Secretogranin-3 protein is a member of the granulin family and plays a critical regulatory role in the biogenesis of secretory granules. As a sorting receptor for intragranule proteins such as chromogranin A/CHGA, SCG3 contributes to granule formation dynamics. SCG3/Secretogranin-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SCG3/Secretogranin-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of SCG3/Secretogranin-3 Protein, Mouse (HEK293, His) is 449 a.a., with molecular weight of 60-70 kDa.

SCG3/Secretogranin-3 Protein, a member of the granin protein family, serves a crucial role in regulating the biogenesis of secretory granules. Functioning as a sorting receptor for intragranular proteins, including chromogranin A/CHGA, SCG3 contributes to the dynamic process of granule formation. Beyond its involvement in granule biogenesis, SCG3 may also play a role in angiogenesis, where it promotes endothelial proliferation, migration, and tube formation through the MEK/ERK signaling pathway. The protein interacts with chromogranin A (CHGA), highlighting its key association with intragranular proteins. Additionally, SCG3 engages in interactions with secretogranin II/SCG2 and carboxypeptidase E (CPE), further emphasizing its intricate involvement in cellular processes related to granule dynamics and angiogenesis.

Mouse

HEK293

C-His

P47867 (F23-L471)

20255  [NCBI]

60-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.