Semaphorin-4A/SEMA4A Protein, Human (HEK293, Fc)

Semaphorin-4A/SEMA4A is the cell surface receptor for PLXNB1, PLXNB2, PLXNB3, and PLXND1 and is essential for intercellular signaling. It induces TIMD2 phosphorylation, inhibits angiogenesis, and collapses axonal growth cones. Semaphorin-4A/SEMA4A Protein, Human (HEK293, Fc) is the recombinant human-derived Semaphorin-4A/SEMA4A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Semaphorin-4A/SEMA4A Protein, Human (HEK293, Fc) is 683 a.a., with molecular weight of ~110 kDa.

Semaphorin-4A (SEMA4A) serves as a cell surface receptor for PLXNB1, PLXNB2, PLXNB3, and PLXND1, playing a pivotal role in cell-cell signaling. This multifaceted protein is implicated in the regulation of glutamatergic and GABAergic synapse development, fostering inhibitory synapses in a PLXNB1-dependent manner and excitatory synapses in a PLXNB2-dependent manner. Additionally, SEMA4A contributes to adaptive immunity by priming antigen-specific T-cells, promoting the differentiation of Th1 T-helper cells, and facilitating the phosphorylation of TIMD2. Furthermore, SEMA4A exerts inhibitory effects on angiogenesis, induces axon growth cone collapse, and hinders axonal extension by providing localized signals that specify territories inaccessible for growing axons. Its intricate role is underscored by interactions with PLXNB1, PLXNB2, PLXNB3, PLXND1, and TIMD2, emphasizing its involvement in diverse cellular processes.

Human

HEK293

C-hFc

Q9H3S1 (M1-H683)

64218  [NCBI]

Approximately 110 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.