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  4. SLC35A1 Protein, Human (sf9, His, MBP, FLAG)

SLC35A1 is a key player in intracellular transport, acting as a transporter to transport CMP-sialic acid from the cytoplasm to the Golgi apparatus. As an antiporter, it exchanges CMP-sialic acid for CMP, maintaining cellular homeostasis. SLC35A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

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Description

SLC35A1 is a key player in intracellular transport, acting as a transporter to transport CMP-sialic acid from the cytoplasm to the Golgi apparatus. As an antiporter, it exchanges CMP-sialic acid for CMP, maintaining cellular homeostasis. SLC35A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
Background

SLC35A1, a pivotal protein in intracellular transport processes, acts as a transporter facilitating the translocation of CMP-sialic acid from the cytosol into the Golgi apparatus. Operating as an antiporter, SLC35A1 engages in the exchange of CMP-sialic acid for CMP, showcasing its dynamic role in maintaining cellular homeostasis. While it binds both CMP-sialic acid and free CMP, SLC35A1 exhibits a higher affinity for free CMP (By similarity). Remarkably, this versatile transporter can also exchange CMP-sialic acid for AMP and UMP, broadening its functional repertoire. Additionally, SLC35A1 demonstrates its involvement in cellular processes by mediating the transport of CDP-ribitol (By similarity).
Species

Human
Source

Sf9 insect cells
Tag

N-MBP;C-Flag;N-8*His
Accession

P78382 (A2-V337)
Gene ID

10559
Molecular Construction
N-term
8*His-MBP
SLC35A1 (A2-V337)
Accession # P78382
Flag
C-term
Protein Length

Partial
Synonyms
SLC35A1; CMP-sialic acid transporter; CMP-SA-Tr; CMP-Sia-Tr; Solute carrier family 35 member A1
AA Sequence

AAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSVGILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFALGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV

Pureté

≥ 90%, as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Instruction de manipulation (2659 KB)

SLC35A1 Protein, Human (sf9, His, MBP, FLAG) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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SLC35A1 Protein, Human (sf9, His, MBP, FLAG)
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