SLC38A1 Protein, Human (sf9, His, MBP, FLAG)

The SLC38A1 protein acts as an symporter, facilitating the pH-dependent cotransport of short-chain neutral amino acids and sodium ions across cell membranes. Crucially, it mediates astrocyte-derived glutamine transport to GABAergic interneurons, contributing to de novo GABA synthesis. SLC38A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC38A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

The SLC38A1 protein functions as a symporter, facilitating the cotransport of short-chain neutral amino acids and sodium ions across the cell membrane from the extracellular to the intracellular side. This electrogenic process is pH-dependent and driven by the electrochemical gradient of Na(+). Notably, SLC38A1 plays a crucial role in mediating the transport of astroglia-derived glutamine into GABAergic interneurons, contributing to the de novo synthesis of the neurotransmitter GABA. Additionally, it is implicated in amino acid transport in placental trophoblasts. The regulatory influence of SLC38A1 extends to synaptic plasticity, highlighting its involvement in fundamental cellular processes with implications for neurotransmitter synthesis and amino acid transport.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

Q9H2H9 (M2-H487)

81539

Partial

MHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.