TGF beta 1/TGFB1 Protein, Rhesus Macaque (HEK293, His)

Transforming growth factor beta-1 (TGF-beta-1) proprotein contains latency-associated peptide (LAP) and active TGF-beta-1 chains, forming a homodimer with disulfide bonds. Upon activation, the proteolytic process releases mature TGF-β-1, allowing it to play regulatory functions in cell growth, differentiation, and immune responses. TGF beta 1/TGFB1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived TGF beta 1/TGFB1 protein, expressed by HEK293 , with N-His labeled tag and C33S mutation.

Transforming growth factor beta-1 (TGF-beta-1) proprotein serves as the precursor for the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, with LAP acting as the regulatory subunit and TGF-beta-1 serving as the active subunit. The proprotein forms a homodimer with disulfide linkages, and upon activation, it undergoes proteolytic processing to release the mature TGF-beta-1, allowing it to exert its regulatory functions in various cellular processes, including cell growth, differentiation, and immune responses. The dimeric structure underscores the importance of the intricate interplay between LAP and TGF-beta-1 in orchestrating the multifaceted activities of TGF-beta-1 within biological systems.

Rhesus Macaque

HEK293

N-8*His

F7HCV5 (L30-S390, C33S)

106992315  [NCBI]

Full Length of Mature Protein

LSTSKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSKDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

Approximately 40-50 kDa & 14-15 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.