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  5. Transforming Growth Factor-β TGF- β
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  7. TGF beta 1/TGFB1 Protein, Rhesus Macaque (HEK293, His)

TGF beta 1/TGFB1 Protein, Rhesus Macaque (HEK293, His)

Cat. No.: HY-P77856
Handling Instructions

Transforming growth factor beta-1 (TGF-beta-1) proprotein, comprising Latency-associated peptide (LAP) and active TGF-beta-1 chains, forms a homodimer with disulfide linkages. Upon activation, proteolytic processing releases mature TGF-beta-1, enabling its regulatory functions in cell growth, differentiation, and immune responses. The dimeric structure emphasizes LAP and TGF-beta-1's intricate interplay in orchestrating multifaceted activities within biological systems. TGF beta 1/TGFB1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived TGF beta 1/TGFB1 protein, expressed by HEK293 , with N-His labeled tag and C33S mutation. The total length of TGF beta 1/TGFB1 Protein, Rhesus Macaque (HEK293, His) is 361 a.a., with molecular weight of 40-50/14-15 kDa.

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Description

Transforming growth factor beta-1 (TGF-beta-1) proprotein, comprising Latency-associated peptide (LAP) and active TGF-beta-1 chains, forms a homodimer with disulfide linkages. Upon activation, proteolytic processing releases mature TGF-beta-1, enabling its regulatory functions in cell growth, differentiation, and immune responses. The dimeric structure emphasizes LAP and TGF-beta-1's intricate interplay in orchestrating multifaceted activities within biological systems. TGF beta 1/TGFB1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived TGF beta 1/TGFB1 protein, expressed by HEK293 , with N-His labeled tag and C33S mutation. The total length of TGF beta 1/TGFB1 Protein, Rhesus Macaque (HEK293, His) is 361 a.a., with molecular weight of 40-50/14-15 kDa.
Background

Transforming growth factor beta-1 (TGF-beta-1) proprotein serves as the precursor for the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, with LAP acting as the regulatory subunit and TGF-beta-1 serving as the active subunit. The proprotein forms a homodimer with disulfide linkages, and upon activation, it undergoes proteolytic processing to release the mature TGF-beta-1, allowing it to exert its regulatory functions in various cellular processes, including cell growth, differentiation, and immune responses. The dimeric structure underscores the importance of the intricate interplay between LAP and TGF-beta-1 in orchestrating the multifaceted activities of TGF-beta-1 within biological systems.
Species

Rhesus Macaque
Source

HEK293
Tag

N-His
Accession

F7HCV5 (L30-S390, C33S)
Gene ID
Molecular Construction
N-term
His
TGFB1 (L30-S390, C33S)
Accession # F7HCV5
C-term
Synonyms
CEDLAP; DPD1; TGF beta1; TGFB; TGFB1; TGFbeta; TGF-beta-1
Molecular Weight

40-50/14-15 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

TGF beta 1/TGFB1 Protein, Rhesus Macaque (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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