TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc)

TMEFF1/Tomoregulin-1 protein may inhibit NODAL and BMP signaling in neural patterning, suggesting a regulatory role in neural development. It has been proposed as a tumor suppressor in brain cancer, emphasizing its importance in mitigating abnormal cell growth. TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMEFF1/Tomoregulin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) is 291 a.a., with molecular weight of ~58.5 kDa.

The TMEFF1/Tomoregulin-1 protein is implicated in potentially inhibiting NODAL and BMP signaling during neural patterning, suggesting its role in the regulatory processes governing neural development. Furthermore, TMEFF1 is proposed to function as a tumor suppressor in brain cancers, underscoring its potential significance in mitigating abnormal cell growth in neural tissues. Additionally, the protein may interact with ST14, implying a molecular association that may contribute to its regulatory and signaling functions. The multifaceted roles of TMEFF1 highlight its importance in both normal developmental processes and its potential involvement in pathological conditions such as brain cancers.

Human

HEK293

C-hFc

Q8IYR6 (S40-V330)

100526694  [NCBI]

SNQPPGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHV

Approximately 65 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.