2. Recombinant Proteins
  3. Cytokines and Growth Factors CD Antigens Biotinylated Proteins
  4. TNF Superfamily Epithelial cell CD Proteins Endothelial cell CD Proteins
  5. TNF Receptor Superfamily TNF-R2/CD120b
  6. TNF Receptor 2 (TNF-R2)
  7. TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His)

TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His)

Cat. No.: HY-P701084
Handling Instructions

TNFRII protein, a receptor with high affinity for TNFSF2/TNF-alpha and lower affinity for TNFSF1/lymphotoxin-alpha, plays a pivotal role in mediating TNF-alpha's metabolic effects. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2, modulating apoptotic pathways. Isoform 2 blocks TNF-alpha-induced apoptosis, suggesting a regulatory role in antagonizing its biological activity. TNFRII interacts with TRAF2, BMX, and activated XPNPEP3, adding complexity to its molecular associations and highlighting its involvement in downstream signaling cascades. TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TNF RII/TNFRSF1B protein, expressed by HEK293 , with C-His labeled tag. The total length of TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) is 235 a.a., with molecular weight of 40-60 kDa.

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Description

TNFRII protein, a receptor with high affinity for TNFSF2/TNF-alpha and lower affinity for TNFSF1/lymphotoxin-alpha, plays a pivotal role in mediating TNF-alpha's metabolic effects. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2, modulating apoptotic pathways. Isoform 2 blocks TNF-alpha-induced apoptosis, suggesting a regulatory role in antagonizing its biological activity. TNFRII interacts with TRAF2, BMX, and activated XPNPEP3, adding complexity to its molecular associations and highlighting its involvement in downstream signaling cascades. TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TNF RII/TNFRSF1B protein, expressed by HEK293 , with C-His labeled tag. The total length of TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) is 235 a.a., with molecular weight of 40-60 kDa.
Background

The TNFRII protein serves as a receptor with a high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2, thereby modulating apoptotic pathways. This receptor plays a pivotal role in mediating the majority of the metabolic effects induced by TNF-alpha. Notably, its isoform 2 exhibits the ability to block TNF-alpha-induced apoptosis, suggesting a regulatory role in antagonizing the biological activity of TNF-alpha. Furthermore, TNFRII binds to TRAF2, highlighting its involvement in downstream signaling cascades. Additionally, interactions with BMX and the activated form of XPNPEP3 further contribute to the complexity of its molecular associations.
Species

Human
Source

HEK293
Tag

C-His
Accession

P20333-1 (L23-D257)
Gene ID
Molecular Construction
N-term
TNFRSF1B (L23-D257)
Accession # P20333-1
His
C-term
Synonyms
CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B
Molecular Weight

40-60 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
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