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ube2l6-human-his

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  • HY-P76688A
    UBE2F Protein, Human (His, Solution)

    NEDD8-conjugating enzyme ube2F; NCE2

    		 Human E. coli
  • HY-P77272
    UBE2W Protein, Human (His)

    Ubiquitin-conjugating enzyme E2 W; UBC-16; Ubiquitin-protein ligase W; UBC16

    		 Human E. coli
    UBE2W Protein, a versatile ubiquitin-conjugating enzyme, accepts ubiquitin from the E1 complex, catalyzing its covalent attachment to diverse substrates. Notably, UBE2W uniquely monoubiquitinates N-termini, including ATXN3, MAPT/TAU, POLR2H/RPB8, and STUB1/CHIP, displaying specificity for disordered N-termini. This monoubiquitination is crucial for degrading misfolded chaperone substrates, as UBE2W mediates STUB1/CHIP monoubiquitination, limiting ubiquitin chain length. Activated by UV irradiation, UBE2W collaborates with FANCL, catalyzing monoubiquitination of FANCD2 in the Fanconi anemia complex, a key step in the DNA damage response pathway. Additionally, UBE2W flexibly catalyzes 'Lys-11'-linked polyubiquitination in vitro. UBE2W Protein, Human (His) is the recombinant human-derived UBE2W protein, expressed by E. coli, with N-His labeled tag. The total length of UBE2W Protein, Human (His) is 151 a.a., with molecular weight of ~18 kDa.
  • HY-P76688
    UBE2F Protein, Human (His)

    NEDD8-conjugating enzyme ube2F; NCE2

    		 Human E. coli
    UBE2F Protein, in the ubiquitin-like NEDD8 conjugation pathway, accepts NEDD8 from the UBA3-NAE1 E1 complex and covalently attaches it to various target proteins. Interacting specifically with the E3 ubiquitin ligase RBX2, not RBX1, the RBX2-UBE2F complex is specialized in neddylating specific targets, notably CUL5. This specific interaction and neddylating activity underscore UBE2F's role in regulating cellular processes through targeted ubiquitination of key substrates. UBE2F Protein, Human (His) is the recombinant human-derived UBE2F protein, expressed by E. coli, with N-His labeled tag. The total length of UBE2F Protein, Human (His) is 185 a.a., with molecular weight of ~25 kDa.
  • HY-P71409
    UBE2T Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 T; Cell Proliferation-Inducing Gene 50 Protein; Ubiquitin Carrier Protein T; Ubiquitin-Protein Ligase T; ube2T

    		 Human E. coli
    UBE2T Protein, an essential ubiquitination component, serves as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin from the E1 complex and catalyzing its covalent attachment to proteins. This multifaceted enzyme catalyzes monoubiquitination, crucial in MMC-induced DNA repair processes. Its significance is highlighted by specific association with the Fanconi anemia complex, collaborating with FANCL for FANCD2 monoubiquitination in the DNA damage response pathway. Beyond DNA repair, UBE2T mediates monoubiquitination of FANCL and FANCI and potentially contributes to BRCA1 ubiquitination and degradation. In vitro, UBE2T promotes various polyubiquitination types, showcasing involvement in diverse ubiquitin-dependent processes. UBE2T Protein, Human (His) is the recombinant human-derived UBE2T protein, expressed by E. coli, with N-6*His labeled tag. The total length of UBE2T Protein, Human (His) is 197 a.a., with molecular weight of 25-30 kDa.
  • HY-P71412
    UBE2Z Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 Z; Uba6-Specific E2 Conjugating Enzyme 1; Use1; Ubiquitin Carrier Protein Z; Ubiquitin-Protein Ligase Z; ube2Z; HOYS7

    		 Human E. coli
    UBE2Z Protein, a catalyst in ubiquitin conjugation, facilitates the covalent attachment of ubiquitin to target proteins. It serves as a specific substrate for UBA6 and is implicated in the regulation of apoptosis. UBE2Z Protein, Human (His) is the recombinant human-derived UBE2Z protein, expressed by E. coli , with N-6*His labeled tag. The total length of UBE2Z Protein, Human (His) is 246 a.a., with molecular weight of ~32.0 kDa.

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