UFC1 Protein, Human (Sf9, His, Strep)

The UFC1 protein catalyzes the second step of ufmylation, accepting UFM1 from UBA5 and forming an intermediate with UFM1. Ufmylation is involved in reticulophagy and interacts with UBA5, UFL1, and UFM1. It also interacts with KIRREL3. UFC1 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UFC1 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UFC1 Protein, Human (Sf9, His, Strep) is 166 a.a., .

UFC1, functioning as an E1-like enzyme, plays a crucial role in the second step of ufmylation, a specific post-translational modification process. This enzyme accepts UFM1 from the E1 enzyme UBA5, forming an intermediate with UFM1 through a thioester linkage. Notably, ufmylation is implicated in reticulophagy (ER-phagy) triggered by endoplasmic reticulum stress. UFC1 engages in interactions with key partners, including UBA5, highlighting its intricate involvement in the ufmylation pathway. Furthermore, UFC1 interacts with UFL1 and KIRREL3, underscoring its potential role in diverse cellular processes beyond ufmylation. These interactions emphasize the significance of UFC1 in orchestrating cellular responses to stress and maintaining cellular homeostasis.

Human

Sf9 insect cells

N-Strep;N-8*His

Q9Y3C8 (A2-Q167)

51506

Approximately 22.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.