VSTM5 Protein, Mouse (HEK293, Fc)

VSTM5 protein, a CNS cell adhesion-like membrane protein, modulates neuronal position and complexity by altering membrane morphology. It influences dendrite and protrusion formation, regulates synapse formation, and controls cortical development. VSTM5 also promotes unstable neuronal spines and oligomerizes for functional versatility. VSTM5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived VSTM5 protein, expressed by HEK293 , with C-hFc labeled tag.

VSTM5 protein, a cell adhesion-like membrane protein of the central nervous system (CNS), plays a crucial role in modulating the position and complexity of central neurons by altering their membrane morphology and dynamics. It actively participates in the formation of neuronal dendrites and protrusions, including dendritic filopodia, and regulates synapse formation by altering dendritic spine morphology and actin distribution during synaptogenesis. Moreover, VSTM5 promotes the formation of unstable neuronal spines, such as thin and branched types, and exerts control over neuronal morphogenesis and migration during cortical development in the brain. Additionally, VSTM5 can oligomerize through cis interactions within the same cell membrane, further contributing to its functional versatility.

Mouse

HEK293

C-hFc

Q9D806 (L28-H146)

69137  [NCBI]

Extracellular Domain

LQSQGVSLYIPQSAINATVQQDILLSVDYICHGVPTIEWKYTPNWGVQRIVEWKPGTPANVSQSHRDRVCTFDNGSIQLFNVSVKDSGYYIVTVTEHPGSSQSGTILLRVSEIRYEDLH

Approximately 55-65 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.