2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Rimexolone

Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.

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Rimexolone

Rimexolone 構造式

CAS 番号 : 49697-38-3

容量 価格（税別） 在庫状況 数量
100 mg $1037 お問い合わせ 3 - 4 Weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks
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Rimexolone 関連抗体

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製品説明

Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2].

Cellular Effect
Cell Line Type Value Description References
HepG2 EC50
0.68 μM
Compound: Rimexolone
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
HepG2 EC50
1.6 μM
Compound: Rimexolone
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
[PMID: 20966043]
HepG2 EC50
4 μM
Compound: Rimexolone
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
Hepatocyte EC50
0.4 μM
Compound: Rimexolone
Activation of PXR in human cryopreserved hepatocytes assessed as induction of CYP3A4
Activation of PXR in human cryopreserved hepatocytes assessed as induction of CYP3A4
[PMID: 20966043]
体外実験

Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rimexolone 関連抗体
体内実験

Rimexolone (Org 6216) (0-450 μg/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male, 8-12 weeks old C57Black/6 mice with antigen induced arthritis[1]
Dosage: 5, 25, 50, 150, 250, 450 μg/mouse
Administration: Intraarticular injection, once
Result: Suppressed the arthritis in a dose-dependent manner.
Significantly prevented osteophyte formation at 450 and 150 μg.
Resulted in a decrease of the inhibition of the chondrocyte proteoglycan synthesis.
臨床実験
分子量

370.52

分子式

C24H34O3
CAS 番号
SMILES

C[C@@]12[C@](C(CC)=O)(C)[C@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Rimexolone Related Classifications

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  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rimexolone49697-38-3Org 6216 RimexelOrg6216Org-6216Glucocorticoid Receptoranti-inflammatory activityocular inflammationminimal systematic effectsarthritisInhibitorinhibitorinhibit

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製品番号:
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