(S)-1-Benzyl-5-carboxy-2-pyrrolidinone  (Synonyms: N-Benzyl-L-pyroglutamic acid)

(S)-1-Benzyl-5-carboxy-2-pyrrolidinone (N-Benzyl-L-pyroglutamic acid) is an orally active H⁺/K⁺-ATPase inhibitor. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone reduces free acidity and total acidity in gastric juice. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone decreases ulcer formation in pylorus-ligated rats. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone can be used for the research of peptic ulcers^[1].

(S)-1-Benzyl-5-carboxy-2-pyrrolidinone (Compound 23) at 10 μM inhibits rat gastric microsomal H⁺/K⁺ ATPase by 44%, with corresponding inhibition rates of 0.86 and 0.93 for free acidity and total acidity, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-1-Benzyl-5-carboxy-2-pyrrolidinone (administered orally; 1 hour prior to pyloric ligation) exhibits in vivo antisecretory activity in the rat pyloric ligation ulcer model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

219.24

C₁₂H₁₃NO₃

7535-59-3

C(N1[C@H](C(O)=O)CCC1=O)C2=CC=CC=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sharma P, et al. alpha-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents. Eur J Med Chem. 2007;42(3):386-393.