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Tnf

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  • HY-P73443
    TNF-alpha/TNFSF2 Protein, Canine

    Tumor Necrosis Factor; Cachectin; Tnf-Alpha; Tnf; Tnfa; Tnfsf2; ICD1

    		 Canine E. coli
    Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine. TNF alpha binds to its receptors, mainly TNFR1 and TNFR2, and then transmits molecular signals for biological functions such as inflammation and cell death. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis. Anti-TNF-α MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse. TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury. TNF-alpha/TNFSF2 Protein, Canine is a recombinant protein produced in E. coli.

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