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Prostacyclin sodium salt (Standard)

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11

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製品番号 製品名 Target 研究分野 構造式
  • HY-A0096R
    Iloprost (Standard)

    Ciloprost (Standard); ZK 36374 (Standard)

    		 Reference Standards Prostaglandin Receptor Endogenous Metabolite Endocrinology Cancer
    Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .
    Iloprost (Standard)
  • HY-14870R
    Selexipag (Standard)

    NS-304 (Standard); ACT-293987 (Standard)

    		 Reference Standards Prostaglandin Receptor Cardiovascular Disease Endocrinology
    Selexipag (Standard) is the analytical standard of Selexipag. This product is intended for research and analytical applications. Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).
    Selexipag (Standard)
  • HY-108912R
    RO1138452 (Standard)

    CAY10441 (Standard)

    		 Prostaglandin Receptor Reference Standards Inflammation/Immunology Endocrinology
    RO1138452 (Standard) is the analytical standard of RO1138452. This product is intended for research and analytical applications. RO1138452 is a potent and selective IP (prostacyclin) receptor antagonist. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3±0.1; in a recombinant IP receptor system, pKi is 8.7±0.06.
    RO1138452 (Standard)
  • HY-13569AR
    Beraprost sodium (Standard)

    TRK-100 (Standard); ML 1129 sodium (Standard)

    		 Reference Standards Prostaglandin Receptor Cardiovascular Disease Inflammation/Immunology
    Beraprost (sodium) (Standard) is the analytical standard of Beraprost (sodium). This product is intended for research and analytical applications. Beraprost sodium, a prostacyclin analog, is a stable and orally active proagent of PGI2. Beraprost sodium is a potent vasodilator, has the potential for pulmonary arterial hypertension treatment through expanding renal vessels, improving microcirculation . Beraprost (sodium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Beraprost sodium (Standard)
  • HY-A0126AR
    Epoprostenol sodium (Standard)

    Prostaglandin I2 sodium salt (Standard); Prostacyclin sodium salt (Standard); Flolan (Standard)

    		 Reference Standards Endogenous Metabolite Cardiovascular Disease
    Epoprostenol (sodium) (Standard) is the analytical standard of Epoprostenol (sodium). This product is intended for research and analytical applications. Epoprostenol sodium (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH) . Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation .
    Epoprostenol sodium (Standard)
  • HY-B1016R
    Trapidil (Standard)

    AR-12008 (Standard)

    		 Reference Standards PDGFR Phosphodiesterase (PDE) Prostaglandin Receptor Cardiovascular Disease Cancer
    Trapidil (Standard) (AR-12008 (Standard)) is the analytical standard of Trapidil (HY-B1016R). This product is intended for research and analytical applications. Trapidil (AR-12008) is an orally active vasodilator and antiplatelet agent. Trapidil antagonizes platelet-derived growth factor (PDGF), inhibits phosphodiesterase, thromboxane A2 synthesis and pro-inflammatory cytokine production. Trapidil promotes prostacyclin biosynthesis, reduces lipid peroxidation, regulates nitric oxide metabolism, and inhibits cell proliferation and migration. Trapidil exerts tissue-protective effects, regulates bone turnover, and inhibits pyroptosis via the GPX3/Nrf2 pathway. Trapidil is applicable to research related to renal ischemia-reperfusion injury, chronic stable angina, restenosis, meningioma, diabetic cardiomyopathy and peripheral nerve crush injury.
    Trapidil (Standard)
  • HY-124124R
    N-Methylnicotinamide (Standard)

    		Reference Standards Endogenous Metabolite Drug Metabolite Cardiovascular Disease Metabolic Disease Cancer
    N-Methylnicotinamide (Standard) is the analytical standard of N-Methylnicotinamide (HY-124124). This product is intended for research and analytical applications. N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway.
    N-Methylnicotinamide (Standard)
  • HY-128932R
    Cefminox sodium (Standard)

    MT-141 (Standard)

    		 Reference Standards Antibiotic Bacterial PPAR Prostaglandin Receptor PTEN Akt mTOR Infection Cardiovascular Disease Endocrinology
    Cefminox (sodium) (MT-141) (Standard) is the analytical standard of Cefminox (sodium). This product is intended for research and analytical applications. Cefminox sodium is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model .
    Cefminox sodium (Standard)
  • HY-B0428BR
    Ozagrel hydrochloride (Standard)

    OKY-046 hydrochloride (Standard)

    		 Reference Standards Prostaglandin Receptor Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Ozagrel hydrochloride (Standard) is the analytical reference standard of Ozagrel hydrochloride (HY-B0428B). Ozagrel hydrochloride (OKY-046 hydrochloride) is a high selective and orally active thromboxane A2 (TXA2) synthase inhibitor with an IC50 of 11 nM. Ozagrel hydrochloride exerts anti-platelet aggregation, vasodilation and anti-inflammatory effects by inhibiting the production of TXA2 and increasing the production of prostacyclin (PGI2). Ozagrel hydrochloride can be used for the study of ischemic stroke, asthma and thromboembolic diseases .
    Ozagrel hydrochloride (Standard)
  • HY-108565R
    BMY 45778 (Standard)

    		Adenylate Cyclase Prostaglandin Receptor Reference Standards Cardiovascular Disease
    BMY 45778 (Standard) is the analytical standard of BMY 45778 (HY-108565). This product is intended for research and analytical applications. BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor .
    BMY 45778 (Standard)
  • HY-106961R
    ONO 1301 (Standard)

    ONO-AP 500-02 (Standard)

    		 Reference Standards Prostaglandin Receptor Cardiovascular Disease
    ONO 1301 (Standard) (ONO-AP 500-02 (Standard)) is the analytical standard of ONO 1301 (HY-106961). This product is intended for research and analytical applications. ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .
    ONO 1301 (Standard)

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