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Results for "

ADAMTS-5

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114996
    ADAMTS-5 Inhibitor
    3 Publications Verification

    		 ADAMTS Inflammation/Immunology
    ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) .
    <em>ADAMTS-5</em> Inhibitor
  • HY-145061
    ADAMTS-5-IN-3

    		ADAMTS Metabolic Disease Inflammation/Immunology
    ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .
    <em>ADAMTS-5</em>-IN-3
  • HY-135710
    ADAMTS-5-IN-2

    		ADAMTS Inflammation/Immunology
    ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis .
    <em>ADAMTS-5</em>-IN-2
  • HY-137430
    Aldumastat

    GLPG1972; S201086

    		 ADAMTS Metabolic Disease
    Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research .
    Aldumastat
  • HY-RS00305
    ADAMTS5 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ADAMTS5 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ADAMTS5 Human Pre-designed siRNA Set A
    ADAMTS5 Human Pre-designed siRNA Set A
  • HY-12270
    T-5224
    45+ Cited Publications

    		 AP-1 MMP Others
    T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .
    T-5224

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