2. Metabolic Enzyme/Protease
  3. ADAMTS
  4. ADAMTS-5-IN-2

ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis.

For research use only. We do not sell to patients.

ADAMTS-5-IN-2 Chemical Structure

ADAMTS-5-IN-2 Chemical Structure

CAS No. : 294648-66-1

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5 mg USD 666 In-stock
10 mg USD 1000 In-stock
25 mg USD 1500 In-stock
50 mg USD 1950 In-stock
100 mg USD 2535 In-stock
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Based on 1 publication(s) in Google Scholar

ADAMTS-5-IN-2 Related Antibodies

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Description

ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2].

Molecular Weight

309.39

Formula

C17H15N3OS
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C1NC2=C(C=C(CC)C=C2)C13SC(C4=CC=CC=C4)=NN3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (323.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2322 mL 16.1608 mL 32.3217 mL
5 mM 0.6464 mL 3.2322 mL 6.4643 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2322 mL 16.1608 mL 32.3217 mL 80.8042 mL
5 mM 0.6464 mL 3.2322 mL 6.4643 mL 16.1608 mL
10 mM 0.3232 mL 1.6161 mL 3.2322 mL 8.0804 mL
15 mM 0.2155 mL 1.0774 mL 2.1548 mL 5.3869 mL
20 mM 0.1616 mL 0.8080 mL 1.6161 mL 4.0402 mL
25 mM 0.1293 mL 0.6464 mL 1.2929 mL 3.2322 mL
30 mM 0.1077 mL 0.5387 mL 1.0774 mL 2.6935 mL
40 mM 0.0808 mL 0.4040 mL 0.8080 mL 2.0201 mL
50 mM 0.0646 mL 0.3232 mL 0.6464 mL 1.6161 mL
60 mM 0.0539 mL 0.2693 mL 0.5387 mL 1.3467 mL
80 mM 0.0404 mL 0.2020 mL 0.4040 mL 1.0101 mL
100 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.8080 mL
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ADAMTS-5-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADAMTS-5-IN-2294648-66-1ADAMTSAdamalysin-like metalloproteinase with thrombospondin motifsInhibitorinhibitorinhibit

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